Epilepsy Drug Resistant Essay
1 INTRODUCTION. Epilepsy is a common chronic neurological disorder that affects more than one million people worldwide. A drug that serves as a first line of treatment is used to control seizures. However, a third of patients with epilepsy suffer from drug-resistant epilepsy because they fail to achieve this. Epilepsy is a common and devastating neurological disorder, affecting more than one million people worldwide. 1 Epilepsy patients have recurrent, unprovoked seizures, which are focal or generalized in nature, 2, 3 As a first line of treatment, ASD antiepileptic drugs are routinely used to control seizures. Stratified subgroup meta-analyses based on the new definition of drug-resistant epilepsy proposed by the ILAE and based on ethnicity revealed no information nor significant associations. For example, Haerian et al. conducted another meta-analysis to evaluate the association between the ABCB, G2677T A, and C3435T loci. In epilepsy, drug resistance is defined as the failure of at least two established antiepileptic drugs, given in adequate dosage, alone or in combination, to release an individual seizure. Abstract. Epilepsy is a long-term neurological condition that results in recurrent seizures. of patients with epilepsy have drug-resistant epilepsy DRE. The KD ketogenic diet is considered an effective alternative treatment for epilepsy patients. The aim of this study was to identify the metabolic role of the KD in epidemiology. When interpreting the incidence and prevalence estimates of drug-resistant epilepsy, it is important to remember that the response to drugs is a dynamic rather than a steady state. a retrospective study following children and adults - after the diagnosis of epilepsy, 923.92 became seizure-free, while EEG showed multifocal discharges and seizures. She finally emerged from status epilepticus after two weeks. One year later, she continues to suffer from drug-resistant, multifocal epilepsy with frequent focal decreased consciousness and focal bilateral tonic-clonic seizures, as well as cognitive decline and depression. Drug-resistant epilepsy DRE. of children with epilepsy. Although some risk factors for DRE have been identified, results are inconsistent. Furthermore, data on the risk factors for epilepsy and its consequences over the lifespan are limited. Drug-resistant epilepsy. Drug-resistant epilepsy. Drug-resistant epilepsy N Engl J Med. 2011, 365 23 2239 author -40. doi:10.1056 NEJMc1111683. Author Hideta Sakemi. PMID: 10.1056 NEJMc summary available. Publication. 1. Clinical predictors of drug-resistant epilepsy in children. Abstract. Background Objective: In a large proportion of epilepsy patients, seizures cannot be controlled. the use of antiepileptic drugs. Drug-resistant epilepsy DRE is defined by the International League Against Epilepsy ILAE as the failure of two tolerated, appropriately chosen and used antiepileptic drug regimens. Objective: To update the American Academy of Neurology's AAN guideline for the treatment of new focal or generalized epilepsy GE with second- and third-generation antiepileptic drugs (AEDs). Methods: AAN criteria were used to systematically review the literature and classify relevant cognitive impairment in PWE. Cognitive impairment in PWE is a consequence of several factors, such as early onset of epilepsy, frequent seizures, frequent interictal discharges, low,-