Mucoadhesive microspheres containing ketorolac for nasal administration Biology essay
Microspheres with HPMC and eudragit RL superior mucoadhesive properties. In vitro drug release studies were conducted up to hours. The best-fit drug release kinetics was achieved. Accepted In this study, a novel mucoadhesive microsphere for nasal administration was developed. developed and researched. The carvedilol loaded PLGA microspheres were; Mucoadhesive materials can increase the time available for drug absorption: starch microspheres were the first example of a mucoadhesive nasal delivery system with microparticles Illum et al. 1987, mucoadhesive microspheres were further investigated for the purpose of nasal delivery Abd El-Hameed and Kellaway, 1997, Pereswetoff, Chitosan has previously been shown to enhance the mucosal absorption of various compounds in a drug delivery system and to have adjuvant activity in the mucosal immune system. response by intranasal administration 10, 11, 12. Microspheres can prolong the residence time of drugs in the nasal mucosa compared to solutions and exert a direct, propranolol-loaded, spray-dried mucoadhesive microspheres for nasal administration. They were developed using hydroxypropyl methylcellulose, chitosan, P by Harikarnpakdee et al. 2006. Furthermore, ApxIIA-containing Man-THM protected immunized mice when exposed to strains of A. pleuropneumoniae. These results suggest that mucoadhesive Man-THM may be a promising candidate for a nasal vaccine delivery system to induce systemic and mucosal immunity that can protect against pathogenic, 1.1. Composition of mucus that hinders drug delivery. Mucus is a heterogeneous water-based gel whose composition varies between species, tissues and individuals 29. This hydrogel contains water ~95 ww, 1-5 wv mucins considered as the structural and functional component of mucus, proteins, electrolytes, carbohydrates. Microspheres of disodium cromoglycate DSCG were prepared with polyacrylic acid or sodium carboxymethylcellulose NaCMC by the spray drying technique. Antihistamines such as levocetirizine dihydrochloride LC are used commercially in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray dried using three additionally ApxIIA-containing Man-THM-protected immunized mice when exposed to strains of A. pleuropneumoniae. These results suggest that mucoadhesive Man-THM may be a promising candidate for a nasal vaccine delivery system to induce systemic and mucosal immunity that can protect against pathogens. The gelucire-containing formulation showed the best mucoadhesive and bioavailability properties. Albertini et al. 2009. Jain et al. 2009 formulated and evaluated nasal mucosal adhesive. The aim of the present research work was to develop spray-dried mucoadhesive microspheres of prochlorperazine PCPZ for intranasal administration with the aim of preventing first-pass metabolism. The nasal bioavailability of fluorescein isothiocyanate-dextran FITC-dextran, Mw, 4300 encapsulated in non-mucoadhesive and mucoadhesive microspheres in New Zealand white rabbits was investigated. According to the literature, cyclodextrin CD microspheres are good mucoadhesive excipients for nasal use. for the administration of gabexate mesylate for treatment. The mucoadhesive polymers have enormous potential for the delivery of therapeutic macromolecules, genes and vaccines through the nasal cavity with improved bioavailability. The aim of this study was to prepare spray-dried mucoadhesive. 45