Bacteriostatic antibiotics and antibacterial drugs Biology essay
Antibiotics change the metabolic state of bacteria, contributing to the resulting death or stasis. The positive relationship between bacterial growth rate and the efficacy of bactericidal antibiotics has been known for decades Eng et al. 1991, Lee et al. 2018, Tuomanen et al. 1986. The implications of this relationship are epitomized by: Antibiotics were initially natural substances. However, today they also include synthetic drugs, which demonstrate their activity against bacteria and kill or inhibit their growth and division. Thanks to these properties, many antibiotics have quickly found practical use in the fight against infectious diseases such as tuberculosis. Antibiotics: classification and mechanisms of action. with an emphasis on molecular perspectives. Ebimieowei and Ibemologi. Microbiology Unit, Dept. Antibacterial agents are a group of materials that selectively destroy bacteria by interfering with the growth or survival of bacteria. With the emergence of the resistance phenomenon of bacterial pathogens against current antibiotics, new drugs often enter the market along with the existing drugs and the alternative compounds. Antibiotic resistance is a pervasive and unforgiving clinical problem exacerbated by a lack of new drugs. therapeutic. The pharmaceutical sector's withdrawal from new antibiotics. 2.1. Purpose change or mutation. To exert an antibacterial effect, combination with the target site is required, where the mutation or modification of the target site will interfere with the normal combination, affecting the effect of antibiotics. The frequency of spontaneous mutations in antibiotics Background Antimicrobial resistance is currently a major global problem. As the pace of the emergence of antimicrobial resistance has outpaced the pace of discovery and introduction of new effective drugs, the medical arsenal now faces a shortage of effective drugs to combat disease, especially those caused by 1. antibiotics. The term "antibiotic" was coined by Selman Waksman, who worked at Rutgers University and discovered the antibiotic streptomycin with Albert Schatz and Elizabeth Bugie. According to Waksman's definition, an antibiotic is a chemical substance produced by microorganisms that: The metabolic state of bacteria contributes significantly to the effectiveness of antibiotics. In this perspective, Stokes et al. emphasize the close relationship between bacterial cell metabolism and antibiotic efficacy, using previous observations to describe areas for further research, with the aim of developing next-generation antibiotics that: a non-antibiotic antimicrobial drug, a biological bacteriostatic agent, useful for the treatment of aerobic vaginitis, bacterial vaginosis and vulvovaginal candidiasis Zhen Pei Jiayi Xiaoqi Meng Yifan Minzi Yang Qinping Zhaojia, Lei, 3The use of these bacteriostatic agents requires an interprofessional team approach to patient care. The prescribing physician will decide which antimicrobial agent to use. This decision should be made in consultation with a board-certified infectious disease pharmacist, in conjunction with the latest antibiogram data - especially in inpatient settings. The era of antibiotics began in s when Alexander Flemming discovered the first antibiotic 'Penicillin'. Narrow Spectrum and Broad Spectrum are the two categories of antibiotics and antibacterial agents, where the effect of the narrow spectrum is limited to the small.