Atherosclerosis An inflammatory disease of the blood vessels Biology essay
The idea of atherosclerosis as an inflammatory disease is based on the finding that immunocompetent cells are abundant in atherosclerotic lesions, and also produce cytokines, especially proinflammatory cytokines.3 The role of immunity, as defined by the role of activated T cells and B cells are much fewer in atherosclerosis. Ultimately, studies of selective anti-inflammatory agents have demonstrated a role for inflammation and the proinflammatory cytokine IL-1β in human atherosclerosis. Arterial blockages, known as atherosclerosis, develop due to excess cholesterol. accumulate in the arterial wall, causing a persistent inflammatory state. The normally quiescent intimal layer of the vessel wall becomes loaded with inflammatory cells, which alter the surrounding endothelial, smooth muscle, and extracellular matrix. Atherosclerosis was once identified as a lipid storage disease but is now recognized as a subacute inflammatory condition of the vessel wall. vessel wall, characterized by infiltration of macrophages and T. Atherosclerosis is the main underlying cause of myocardial infarction and stroke. Atherosclerotic cardiovascular disease is characterized by a chronic inflammatory response in medium to large individuals. Vascular diseases caused by atherosclerosis remain one of the leading causes of mortality and morbidity worldwide and are responsible for an enormous economic burden on healthcare systems. Atherosclerosis is a chronic inflammatory disease of the blood vessels that can begin in childhood and develop over decades. Atherosclerosis is a chronic inflammatory disease that affects medium and large arteries. It begins after birth and its progression depends on several factors: Traditional Triad. 1 Introduction. Over the past two decades, clinical and experimental studies have shown that atherosclerosis is a low-grade, sterile inflammatory disease 1,2. Systemic and local inflammation play a central role in the development and progression of cardiovascular disease, from endothelial dysfunction to clinical. The cardiovascular system of the circulatory system supplies nutrients and oxygen to all cells in the body. It consists of the heart and blood vessels that run throughout the body. The arteries, In the s, most researchers believed that atherosclerosis was the buildup of fatty deposits known as plaques in arteries, which can contribute to heart attacks and strokes. Peripheral artery disease is usually caused by atherosclerosis. Other causes may include inflammation of the blood vessels, injury, or exposure to radiation. Risk factors include: PAD affects millions of adults worldwide, and the incidence of PAD increases to a similar level in people over the age. 1. Inflammation and initiation of lesions. Inflammation appears to be associated with the earliest stage in the development of atherosclerotic plaques, the formation of fatty streaks. Figure A and B. Experimentalists typically provoke the formation of atherosclerotic lesions in animals by initiating a diet rich in cholesterol and saturated fat, and/or by introducing tobacco use. global cause of death, responsible for more million deaths per year or a percentage of deaths among people aged and older, for men, for women. It is the most preventable cause of cardiovascular disease, of which there are many. Atherosclerosis is the leading risk factor for cardiovascular disease, which is the leading cause of death worldwide. Atherosclerosis is initiated by activation of the endothelium and, followed by.