Receptor tyrosine kinases essay




Since the discovery of the first receptor tyrosine kinase RTK more than a quarter of a century ago, many members of this family of cell surface receptors have emerged as key regulators of crucial cellular processes, such as proliferation and differentiation, cell survival and metabolism, migration, and cell cycle control Blume, Tyrosine phosphorylation by protein tyrosine kinases PTKs is a type of post-translational modification. Tec kinases, a subfamily of non-receptor PTKs, were originally discovered in the hematopoietic system and include five members: Tec, Btk, Itk Emt Tsk, Etk Bmx, and Txk Rlk. Especially with the advancement of modern research,





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