How Nuclear Compartmentalization Affects Gene Expression of Chromosome Regions Biology Essay




In other words, we propose a model of localized chromatin interaction in the nuclear subdomain, in which the status of a local chromatin interaction in the nuclear subdomain has a more important impact on the regulation of gene expression in the response to environmental stress than chromosome territories. compartments, TADs, D conformation of the genome plays a central role in many cellular functions, including gene expression and DNA replication 1,2,3,4. 3D interactions occur as a result of biological functions. In a third study, differences in gene expression across the chromosome were measured after attachment of the chromosome to the inner nuclear membrane. A few genes, some close and some far from the integrated LacO cassettes, showed repressed transcription, but expression was not incompatible with the peripheral location Finlan et al. The importance of higher-order nuclear structure and compartmentalization for the control of cell life is now beyond question. The genomes of higher eukaryotes are organized into certain chromosome territories, and the three-dimensional organization of these territories may be intimately related to genomic function and global regulation of genes. If transcription causes a decondensation of chromosome territories, in its absence chromatin would adopt a condensed default state. Indeed, a condensation of the human territory is observed by light microscopy when transcription is inhibited, and by electron microscopy through chromatin fibers at the Balbani ring, gene rich, 17, 19, close to the nuclear center, while gene poor, close to the nuclear periphery for fibroblasts. Because the radial organization of chromosomes in the nucleus affects the nuclear positioning of translocation chromosomes, Croft et al. 1999, and proximity to the nuclear edge can directly influence gene expression in mammalian cells Finlan et al. 2008 Reddy et al. 2008 Deniaud and we reasoned that a possible combination of epigenetic state, nuclear tethering, physical forces, gene expression, and replication timing RT could all influence the establishment and change of chromosome compartments. We review the causes and implications of genomic regions undergoing compartment switching that alters their physicality. Subnuclear compartmentalization has been proposed to play an important role in gene regulation by separating active and inactive parts of the genome in different physical and biochemical environments. is generally considered to be repressive of gene expression, although this effect is. It was shown that gene-dense loci can form giant loops that extend beyond their corresponding chromosome territories. C Francastel, D Sch beler, DI Martin, M Groudine, Nuclear compartmentalization and, within territories, the position of individual genes relative to other chromosomes and nuclear landmarks can influence their transcriptional state. In differentiated cells, although expressed genes can localize within territories, the three most active loci are located between chromosome territories, often oriented toward the,





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