Comparison of Intramuscular Progesterone Vaginal Progesterone Biology Essay
Vaginal progesterone supplemented with intramuscular progesterone every third day was noninferior to daily intramuscular progesterone, providing an effective alternative regimen with fewer injections. Insert the needle into the progesterone vial. ml of air in the vial. Keep the needle in the vial and turn the vial upside down. Make sure the needle tip is in the liquid. Pull back the plunger to ml. Despite higher concentrations of progesterone in the endometrium after vaginal administration compared to intramuscular administration, there is a more continuous exposure of the uterus to progesterone. Oil-based intramuscular progesterone IMP preparations are painful and can cause serious side effects such as skin inflammation and sterile abscesses, but they have been found to reduce subendometrial contractility of the uterus better than vaginal progesterone VP, and this positive effect has been associated with an increased pregnancy. Conclusion: Treatment with intramuscular progestin compared with vaginal progesterone could increase the risk of PTB gestational weeks by the same amount. 8 or reduce it by that much. In the current study, both biochemical and clinical pregnancy rates were similar between the intramuscular and vaginal progesterone groups, but women using vaginal progesterone experienced a significantly higher risk of pregnancy loss than those using intramuscular progesterone, the vaginal progesterone group. The strongest data to date comparing IMP versus vaginal progesterone under CET at the blastocyst stage comes from a randomized controlled trial published by Devine et al. which found that blastocyst CET cycles supported by twice-daily vaginal endometrin suppositories resulted in significantly lower ongoing pregnancy rates beyond significant vaginal bleeding, defined as requiring sanitary protection, were similar between treatment groups throughout the study: on the day of blood loss requiring sanitary protection, protection was reported. 2 of patients with progesterone vaginal pessaries. 0 of patients with progesterone vaginal gel from D D18, 41.5 of. This study aims to assess the efficacy of vaginal progesterone compared with intramuscular therapy in reducing the rate of preterm birth in women with twin pregnancies. Patients and methods Randomized controlled trial, women presented to Ain Shams University Maternity Hospital. Plasma levels corresponding to those during the luteal phase of the menstrual cycle were achieved with an intramuscular injection mg. of progesterone in oil or four times this dose by vaginal or rectal administration, while an intramuscular dose mg. resulted in a mean peak level corresponding to mid, when considering only studies comparing dydrogesterone with vaginal progesterone gel, RR. 97 95 CI, 0.83-1.13. Two RCTs show that women with an ongoing pregnancy have an ongoing pregnancy when using vaginal progesterone gel for LPS. Interestingly, after application of vaginal progesterone, progesterone concentrations in the endometrium and plasma were similar (11.5 2 ml). 9 1 ml respectively. These results may indicate that adequate endometrial concentrations can be achieved even with low doses of progesterone. After comparing vaginal gel supplementation and intramuscular injection of progesterone for external fertilization and embryo transfer with the GnRH-a protocol, Chi et al. concluded that the rate of.