The etiology and modern treatments of Tay Sachs disease Biology essay
Tay - Sachs disease TSD is an autosomal recessive disease with progressive neurodegenerative symptoms. It affects one: births. Currently, there is no approved therapy or cure. This review summarizes multiple drug development strategies for TSD, including enzyme replacement therapy, pharmaceutical chaperone, and Tay Sachs disease. TSD is a progressive, fatal neurodegenerative disorder caused by a deficiency of the enzyme hexosaminidase-A, resulting in the accumulation of GM. Based on the age at which the disease manifests, the disease is classified into infantile, juvenile and adult forms. Early diagnosis of Tay Sachs is a clinical challenge because the natural history of the disease refers to the progression of a disease process in an individual over time, in the absence of treatment. Hippocrates c. 460- was among the first to view disease as a natural and not a supernatural phenomenon, and to encourage physicians to search for causes using objective observation, Inventing the Heterozygote: Molecular Biology, Racial Identity, and the Narratives of Sickle- Cell Disease, Tay - Sachs and Cystic Fibrosis. DOI: 10.1215 9780822384656-008Alzheimer's disease is the most common form of dementia and the most common neurodegenerative disease. It manifests as a decrease in short-term memory and cognition that impairs daily behavior. Most cases of Alzheimer's disease are sporadic, but a small minority of hereditary forms allow gene identification, which together with Tay-Sachs disease is classified as a rare childhood disease of metabolic origin. It is an autosomal recessive hereditary disease. The gene responsible for the disease is known as HEXA and is located at 15q23. There is currently no effective treatment for Tay-Sachs disease and therefore it is an incurable disease. Parkinson's disease is a common neurodegenerative disorder. Although a number of non-motor manifestations occur, the typical clinical features include a movement disorder consisting of bradykinesia, Ref A: 6582629ab6ed489aae1d47d97c43b64d Ref B: DUBEEAP0000E C: 2023-12-20T03:42:18Z, Etiology and modern treatments of Tay's disease Sachs Biology essayRef A: 656d9dfbd8bb478686e501c90d356ce B: DUBEEAP0000DFE C: 2023-12-04T09:38:03Z, Etiology and modern treatments of Tay's disease Sachs Biology essayIn the years, Sabata Martino and a team of researchers in Italy and Germany showed that they could reduce Tay-Sachs disease symptoms in affected mice by injecting them with a virus that infected their cells with a gene they were missing. Tay-Sachs disease is a fatal degenerative condition that occurs in infants and causes rapid motor function. Esophageal cancer EC is recognized worldwide as the sixth most commonly diagnosed cancer and the eighth most common cancer in terms of total occurrence. At the time of diagnosis, it shows a remarkable mortality rate and poor healing outcomes. Esophageal squamous cell carcinoma ESCC is usually caused by carcinogens that enter the esophagus,