Designing a scaffold for bone growth biology essay
In recent years, bone tissue engineering has emerged as a promising solution for large bone defects. Moreover, thanks to the emergence and development of the smart metamaterial and advanced optimization, tissue engineering is now an emerging approach that aims to replace or regenerate diseased or damaged organs with engineering constructs. Given the key role of growth factors GFs in the tissue regeneration process, these biomolecules are considered an important part of the tissue engineering process. Thus, the presence of successful material design for bone tissue engineering requires an understanding of the composition and structure of natural bone tissue, as well as the appropriate selection of biomimetic natural or. Abstract. Bone tissue engineering has continuously evolved since the concept of “tissue engineering” was proposed. Biomaterials used as basic materials for scaffold fabrication play a crucial role in bone tissue engineering. This article first introduces a literature review strategy. Mechanical properties of bone depend on age, anatomical location and sex. The elastic modulus is the biomechanical property of bone that is attracting increased interest due to its critical importance in characterizing bone pathologies and guiding the design of bone scaffolds 10 , 12 . Mechanical stimulation has a major influence on bone. A BTE study also found more bone formation in trabecular bone. defect of a metaphyseal bone, which was implanted by a bone scaffold with growth factor, but delayed cortical healing Raina et al. 2019. To guide cortical regeneration, the cortical defect was endosteally sealed with a collagen membrane loaded with growth factor: Hing 2005 recently provided a valuable insight into these important issues with a view to optimizing the design and manufacture of scaffolding. A very challenging field of research concerns the strategies for conferring special “biological” properties on tissue engineering scaffolds, with particular reference to the use of bioactive glasses.