Essay on Epithelial to Mesenchymal Transition
The roles of epithelial to mesenchymal transition EMT and mesenchymal to epithelial transition MET in breast cancer bone metastasis: potential targets for prevention and treatment. J Clin, 2 4 264-82. PMID: 26237148 Yang J and Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of, Introduction. The majority of human cancers arise in epithelial tissues. A defining characteristic of epithelial cells is that they can establish strong intercellular adhesion, which limits cell mobility. However, epithelial cells are able to lose their epithelial characteristics via epithelial-to-mesenchymal transition EMT, a reprogramming. an epithelial phenotype is called mesenchymal-to-epithelial transition. MET Mesenchymal cells are spindle-shaped with a fibroblast-like morphology, have no adhesive capacity and are highly motile. They lack junctional complexes and specialization of the plasma membrane to apical acidic conditions-mediated ROR promotes the epithelial-mesenchymal transition EMT. To confirm the function of acid-induced ROR-EMT in hepatocellular carcinoma, we measured and compared the changes in the levels of EMT. EMT-related genes, such as those encoding N-cadherin, vimentin, Snail ZEB1, in Epithelial-mesenchymal transition. EMT is a complex reversible biological process that occurs in epithelial cells and is characterized by the loss of epithelium and the acquisition of mesenchymal genes. features 1,2. Although initially considered a binary process, a growing body of evidence indicates that EMT occurs in an epithelial-mesenchymal transition. EMT is a transdifferentiation process in which epithelial cells acquire characteristics typical of mesenchymal cells. In this dynamic and reversible transition, epithelial cells lose typical features such as junctions and baso-apical polarity, while acquiring back-to-front polarity along with the ability to do so. 1 Introduction. Epithelial-mesenchymal transition EMT is considered a reversible biological process important for normal embryogenesis and organ development from monolayer to multilayer organisms, especially during gastrulation and migration of neural crest cells. The neural crest cells, originate from non-neural,