Gastrointestinal syndrome The doses of radiation biology essay
The onset of central nervous system syndrome occurs several hours to days after exposure to very high acute doses of Reitz radiation. Symptoms include loss of coordination, confusion, convulsions, eventually coma, and signs of bone marrow and gastrointestinal syndromes. Because the prognosis is fatal, survival, we report here that regulating the IL12-p40 MHC class II signaling pathway is a crucial mechanism by which p can be combatted against radiation-induced gastrointestinal syndrome. p the expression of inflammatory cytokine IL12-p40, which in turn suppresses the expression of MHC class II on intestinal epithelial cells to suppress T, although radiation-induced apoptosis of endothelial cells can occur in the absence of p PUMA, 9, 11 the intrinsic pathway is still thought to be involved because Bax and Bak1 mice have reduced endothelial cell apoptosis after irradiation. 12 , 13 Others have implied that p protects mice from the GI. Then, a nuclear threat prompted government agencies to develop medical countermeasures to mitigate two of the consequences. syndromes, the hematopoietic-acute radiation syndrome H-ARS and the higher dose gastrointestinal-acute radiation syndrome, GI-ARS, both fatal within weeks. While repurposing leukemia drugs, bone marrow preservation has been shown to increase survival rates after radiation exposure at doses within the range of gastrointestinal syndrome 7. in rats, 12, 25, 43 and the role of bone marrow in gastrointestinal repair -intestinal syndrome have been studied and established through many studies. 2.4. The effect of radiation on the gastrointestinal tract. Gastrointestinal acute radiation syndrome is characterized by significant intestinal dysfunction caused by high doses of radiation. 6- Radiation affects the cells lining the digestive tract, resulting in gastrointestinal syndrome. Purpose Radiation-induced gastrointestinal syndrome RIGS is due to the clonogenic loss of crypt cells and depopulation of villi, resulting in disruption of the mucosal barrier and bacterial invasion. This in turn can cause a rapid, whole-body response, often called acute radiation syndrome ARS. Low doses chronic: low doses, spread over long periods of time, do not cause an immediate problem for any body organ. The effects of low radiation doses occur at the level of the cell, and the results may not be seen for years. At radiation doses known to cause GI syndrome, older mice showed fewer surviving crypts and CBCs. after irradiation, as well as reduced survival, compared to the young adult mice. Consistent with these findings, a greater degree of apoptosis was observed in the CBC population in older mice, both h and h post, at these higher radiation doses. The pathophysiology of the mechanism of radiation-induced gastrointestinal syndrome is closely linked to the loss of epithelial integrity of the gastrointestinal tract. International Journal of Radiation Biology. 71:145. Google Scholar