Orally controlled drug delivery systems increase drug bioavailability Biology essay
1 Introduction. Oral administration is the most preferred route of drug delivery due to its simplicity, convenience and patient acceptance, especially in the case of repeat dosing for chronic therapy 1 - 3 . Unlike intravenous administration, which is likely to result in toxic blood levels after injection and sometimes. Dosage forms that can be retained in the stomach are called gastroretentive drug delivery systems GRDDS, GRDDS can improve the controlled release of drugs with an absorption window by continuously releasing the drug for an extended period of time before it reaches the site of absorption, thus ensuring optimal bioavailability. Drugs with a, The de novo design of an oral controlled drug delivery system DDS should be primarily aimed at achieving a more predictable and increased bioavailability of drugs. However, the development process is hampered by several physiological problems, such as the inability to confine and localize the DDS within desired regions of the solid lipid nanoparticles. SLNs have the potential to encapsulate drugs for oral administration. Slow erosion of the lipid controls drug release, prolonging plasma residence time and “dampening” peak plasma concentrations. In vitro release is delayed compared to other formulations. 82 - 85 Controlled drug delivery systems are designed to maintain drug concentrations within the blood. therapeutic range over an extended period of time, ensuring sustained and controlled release of the. medicine. This. Introduction. Nanotechnology is characterized as the creation, control and use of materials at the nanoscale. Nanoparticles are characterized as materials with smaller nm size. The bioavailability of bioactive compounds after oral administration can be improved by using nanoencapsulation to deliver targeted drugs.