Background and meaning of nerve growth factor biology essay
NGF background. NGF was initially discovered in s as a tumor tissue-produced soluble factor that promotes the growth and differentiation of sensory and sympathetic ganglia. 7, was the first growth factor to be identified and its discovery represented a milestone in developmental neurobiology. Highlighting resistance to hormone therapy and disease progression is the greatest challenge in the clinical management of PC prostate cancer. Drugs currently used in PC therapy initially exhibit potent antitumor effects, but a growth factor, as initially defined, is a secreted biologically active molecule that can influence cell growth. This definition is extensive to include secreted molecules that promote or inhibit mitosis or influence cellular differentiation. Growth factors can act on specific cell surface receptors that then transmit their growth signals. Osteoarthritis OA is the most common form of joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor NGF in pain generation, the relationship between NGF and OA pain, and pathogenic factors interleukin-1β, transforming growth factor -β1, mechanical loading, and adipokines. Here we review evidence regarding the role of nerve growth factor NGF, the first discovered growth factor in cancer biology, with a particular focus on its role in cancer cell death and survival. The balance between cell death and survival in an organism is key to maintaining tissue homeostasis. The nerve growth factor: its role in growth, differentiation and function of the sympathetic adrenergic neuron RITA LEVI-MONTALCINI Laboratory of Cell Biology, Rome Italy and Department of Biology, Washington University, St, Louis, Mo. VS THE SYMPATHETIC NERVE CELL: A BRIEF BIOGRAPHICAL SKETCH Over the course of, the acetabular labrum improves the stability of the hip joint and plays a key role in the progression of osteoarthritis. Labral nerve endings contribute to hip osteoarthritis pain. In addition, vascular endothelial growth factor VEGF and nerve growth factor NGF are associated with pain. Therefore, we analyzed the VEGF and NGF expression levels in the labrum,