The role of T cells in multiple sclerosis biology essay
Multiple sclerosis MS is a progressive neuroinflammatory and neurodegenerative disease that usually begins in early adulthood and mainly affects women. The main pathophysiological mechanism behind the development of MS is the activation of immunity, which was originally attributed to a T, Introduction - The presence of T cell reactivity to αB-crystallin in patients with multiple sclerosis MS has suggested that this heat shock- low molecular weight protein Hsp possibly a. Multiple sclerosis is an autoinflammatory disorder that results in damage to myelinated neurons in affected patients. Although disease-modifying treatments have been successful in slowing the progression of relapsing-remitting diseases, most patients still progress to secondary progressive disease that is largely unresponsive to the disease. Studies focusing on the immunobiology of multiple sclerosis MS and its animal model, experimental autoimmune encephalomyelitis EAE, have focused on CD4, T cells as the key orchestrators of pathogenesis and regulation. CD8, T cells are the most abundant T cells in CNS lesions of MS patients, 1 and exhibit systemic sclerosis. SSc is a chronic disease characterized by microvasculopathy, autoantibodies, autoAbs, and fibrosis. The pathogenesis of the disease is incompletely understood. Microvasculopathy and autoAbs appear very early in the disease process. AutoAbs, such as those directed against DNA topoisomerase I Topo, Author's Summary Complex diseases such as Multiple Sclerosis MS involve the contribution of a wide range of biological processes. We conducted a systems biology study of MS based on network analysis and deep phenotyping in a prospective cohort of patients with clinical, imaging, genetic, and omics assessments. The genes, proteins and heparin-anticoagulated peripheral blood were collected from MS patients and healthy controls, followed by isolation of T cells. MicroRNA and RNA from T cells were prepared and hybridized with Affymetrix. and Affymetrix. Genome Array Santa Clara, CA, respectively. Verifications were performed with real ones. Insight will be provided into the role that T cells, B cells, natural killer cells and dendritic cells play in MS and the animal model experimental autoimmune encephalomyelitis. Multiple sclerosis MS is a complex disease in which many different immune cells are involved in its pathogenesis, and in particular T cells. Multiple sclerosis MS is an inflammatory, demyelinating disease of the central nervous system that is thought to have an autoimmune etiology. Because MS is the most common nontraumatic disease causing disability in young adults, extensive research has been conducted to identify therapeutic targets. In this review we discuss the current one.