Analysis of Familial Hypercholesterolemia Biology Essay
Familial hypercholesterolemia FH is the most common autosomal dominant genetic disorder, affecting millions of patients worldwide and characterized by lifelong elevations in LDL-C low-density lipoprotein cholesterol. hypercholesterolemia HoFH is the rare form of familial hypercholesterolemia that causes extremely high LDL-C levels of low-density lipoprotein cholesterol, leading to atherosclerosis. Results: Eleven general population studies and two patient studies were included in a systematic review of general population studies in a random effects study. meta-analysis. The overall pooled FH. Background and Objectives: Familial hypercholesterolemia FH is one of the most important risk factors for the progression of atherosclerosis and coronary artery disease. This study focused on identifying the dysregulated molecular pathways and core genes that are differentially regulated in FH and to identify the possible genetic factors and pathways. Familial hypercholesterolemia FH is characterized by significantly elevated low-density lipoprotein cholesterol LDL-C leading to deposition of atherosclerotic plaques. in the coronary arteries and proximal aorta at a young age and increases the risk of premature cardiovascular events such as angina pectoris and myocardial infarction, familial hypercholesterolemia. Carriers of any FH variant dl greater maximum LDL-C than sequenced noncarriers in a mixed linear model analysis P, 1.8 10 −20. Council on Functional Genomics Translational Biology, Council on Lifestyle Cardiometabolic Health, The Family Agenda, The cornerstone of treatment for hypercholesterolemia is a healthy lifestyle, optimal weight, no smoking, minutes of exercise per week, and a diet low in saturated and trans- fatty acids and enriched with fiber, fruit and vegetables and oily fish. Plant stanols in a dose of gd can help lower LDL-C levels. Familial hypercholesterolemia FH is a Mendelian disorder caused by pathogenic DNA variants in related genes LDLR APOB or PCSK9, characterized by elevated LDL low-density lipoprotein cholesterol concentrations and risk of coronary artery disease CAD. 1. Cardiovascular disease in heterozygous familial hypercholesterolemia HeFH, the most common monogenic disorder of human metabolism, is largely caused by low-density lipoprotein LDL cholesterol concentrations. Because rates of cardiovascular disease in this population vary considerably beyond lifetime LDL, 1. Introduction. Heterozygous familial hypercholesterolemia HeFH, the most common monogenic metabolic disorder in humans, caused by mutations in the genes encoding the low-density lipoprotein LDL receptor apolipoprotein Apo B-100 proprotein convertase subtilisin kexin-PCSK9. or Apo E brings high LDL,