Overlooked etiology for chemotherapy-induced oral mucositis Biology essay
Once elucidated, the involvement of microbial ecological shifts in the pathogenesis of chemotherapy-induced oral mucositis may contribute to its initiation. Oral mucositis, characterized by an inflammatory response. and cell loss in the epithelial cells lining the oral cavity is one of the most disabling. Their mechanism of action usually determines the side effects. side effects include: nausea, myelosuppression and various oral manifestations; The morbidity of oral mucositis includes pain, feeding difficulties, and risk of infection, potentially leading to interruptions or dose reductions of cancer therapy; In this review, mucositis is described in detail, discussing the impact of standard chemo-radiotherapy and targeted therapy on the development of mucositis. The OM and pain severity were evaluated on the 14th day of the study after chemotherapy using the WHO Mucositis Assessment and Numerical Pain Rating Scale. Results: In the majority of patients. Oral mucositis and selective elimination of the oral flora in head and neck cancer patients receiving radiotherapy: a double-blind, randomized clinical trial. Brother J Cancer. 88 7 1012-1016. PMC free article, Google Scholar Stringer AM. 2013. Interaction between host cells and microbes in chemotherapy-induced mucositis. Nutrients. 5 5 1488-1499Introduction. Mucositis caused by antineoplastic drugs is a major, dose-limiting, and costly side effect of cancer therapy. The ulcerative lesions caused by mucotoxic chemoradiotherapy are painful, limit oral intake and, most importantly, act as sites of secondary infection and entry points for the endogenous oral flora. Oral mucositis is one of the most common side effects of cancer treatment, chemotherapy and/or radiotherapy. It is an inflammatory process that affects the mucous membrane of the oral cavity, causing erythematous areas in combination with ulcers that can reach a large size. The real importance of oral mucositis is its complications. Oral mucositis OM is an acute inflammatory, ulcerative condition of the oral mucosa that often occurs as a result of chemotherapy and/or radiotherapy. Treatments to control cancer, such as radiotherapy, cisplatin-fluorouracil 5-FU, generate ROS that target neoplastic cell DNA, resulting in cell damage and death. We now characterize a mouse model of digestive tract mucositis - Fluoruracil 5-FU. Mice received -FU intravenously, kg or saline h weeks. After the initial injection, mice were clinically monitored for weight loss and diarrhea. The incidence and extent of oral mucositis was assessed macroscopically.