An overview of the essay on the biology of the rabies virus
Rabies or Hydrophobia is a disease that makes dogs sick. In many eastern and western countries, dogs are vaccinated against it, but there is no control yet. Rabies is caused by a virus that attacks the nervous system and is later excreted through saliva. A person or animal can become a victim of rabies in many ways, including: Biting. b. Components of rabies virus modulate its neuroinvasiveness and neurovirulence. The rabies virus glycoprotein has been shown to play a key role in several steps of rabies pathogenesis, viral uptake from the site of inoculation, axonal transport and transsynaptic distribution in the central nervous system, as well as viral distribution in the nervous system. crossing the blood-brain barrier is a challenge. The use of peptide sequences derived from viruses with a central nervous system-CNS tropism is an elegant option. A prominent example is the rabies virus glycopeptide-29 RVG-29, which is said to enable targeted brain delivery. Although the mechanism of entry is rabies, rabies is a zoonotic disease caused by infection with viruses of the genus Lyssavirus, which are transmitted through the saliva of an infected animal. Dogs are the main reservoir for rabies viruses, and dog bites are responsible for 99% of human cases. The virus first infects the peripheral motor neurons and symptoms appear after the, The remaining six so-called rabies-related viruses, Lagos bat virus Mokola virus Duvenhage virus European bat. and the recently discovered Australian bat, 80 can cause a neurological disease identical to rabies 17 and mainly, Research on bat viruses dates back to the s, when Joseph Pawan first identified the rabies virus in bats and experimentally infected several bat species with the virus. in, 11. Autophagy may serve a dual role in viral infections, with pro- or antiviral functions depending on the virus and the stage of the viral replication cycle. Negative-stranded RNA viruses, including RABV, can induce autophagy during infection. 79 - autophagy induced by viruses can eliminate intracellular viruses. INTRODUCTION. Lyssavirus, a genus of the family Rhabdoviridae of the order Mononegavirales, consists of single-stranded, negative-sense RNA viruses, which infect mammals and cause fatal acute viral encephalomyelitis known as rabies. There are high levels of nucleotide and amino acid sequence homology between lyssaviruses, ABSTRACT. The established concept that rabies is transmitted through bites has recently been weakened by reports that the disease occurs after exposure of animals and humans to the disease without a bite. The major non-biting route appears to be the respiratory infection found in wild animals and in laboratory workers handling contaminated materials. Rabies is a fatal but preventable viral disease. It can be transmitted to people and pets through the bites and scratches of an infected animal. Rabies mainly affects the central nervous system, leading to serious brain disease and death if medical care is not provided before symptoms begin. Immediate medical attention if rabies is suspected. Rabies virus RABV is a contagious and neurotropic pathogen that causes rabies and infects humans and almost all warm-blooded animals, posing a major threat to humans and public safety. Innate immunity is known to be the host's crucial first line of defense against viral infections.,