Essay on Engineering Microparticle Drug Delivery Systems
Microparticle chitosan delivery systems containing clotrimazole were prepared by a spray-drying technique using -phosphate as an ionic cross-linking agent. The impact of cross-linking ratio on microparticle characteristics was evaluated. Drug-free and drug-loaded unmodified or ion-crosslinked chitosan microparticles were investigated for, here, the development of a magnetically responsive microparticle system for pulmonary delivery of an anti-tuberculosis drug candidate. including tissue engineering, drug delivery systems, introduction. Drug delivery DD refers to the methods, formulations, technologies and processes involved in transporting a pharmaceutical substance into the body to achieve the desired therapeutic effect. includes the approaches of administering medicinal compounds to humans and animals to achieve therapeutic. PD release was suppressed. 2, but increased by. 8. 4. These properties were suitable for the specific delivery of Ch-SP-MS to the lower intestines and the specific delivery of PD. It was suggested that Ch-SP-MS EuL and Ch-SP-MS EuS are useful as a specific drug delivery system for IBD sites, as shown in. Microparticles are defined as particles. dispersions or solid particles with a size in the. range -1000 m. The drug is dissolved, contained, encapsulated or adhered to a. microparticle. 1 Introduction. Drug Delivery DD generally represents a method of delivering therapeutic complexes to biological systems. DD microstructures control and regulate various processes of liberation, absorption, dispersion and elimination of biomedical entities. The routes by which drugs can be delivered or absorbed into the body are numerous. In drug delivery systems, they are limited to match the complexity of the application because they aim to produce the content in response to a specific bimolecular triggering mechanism of action. Nanocapsules also have the efficient applications in various fields of agrochemicals, wastewater treatment, genetic engineering, cosmetics and micronized polymeric particles. They play an important role as drug delivery systems aimed at providing sustained or controlled release of drugs over extended periods of time. to improve the bioavailability of drugs, to protect drugs from the environment and reduce their side effects Pavan Kumar et al. Satheesh Madhav amp Kala, Microparticles are defined as particles. dispersions or solid particles with a size in the. range -1000 m. The drug is dissolved, contained, encapsulated or adhered to a. microparticle. Several approaches have been taken to develop effective drug delivery systems for the controlled release of a wide variety of compounds. In this work, a microparticle system was chosen that would be loaded with the essential amino acid L-lysine, a molecule that has recently attracted attention for its involvement in pro-angiogenic, pro-,