Simultaneous determination of chlorpheniramine maleate Biology essay
Ahmed Kareem Abbas, Khalaf F. Alsamarrai Innovation and validation of a new RP-HPLC method for the simultaneous determination of chlorpheniramine maleate, phenylphrine HCl, glycerylguaiacolate, methylparaben, propylparaben and yellow pharmaceutical syrup. AIP Conference, 2394 1, A high performance reverse phase liquid chromatographic method was developed for the estimation of paracetamol, guaifenesin, phenylephrine HCl, chlorpheniramine maleate and bromhexine HCL in a single tablet dosage form. This method proved to be simple, accurate, precise and robust. Several methods for the determination of chlorpheniramine maleate in pharmaceutical formulations have been reported in the literature. An aqueous titration method was proposed in which the excess HCl not absorbed by the free base of the drug is back-titrated. In addition, acid-base titrations were performed potentiometrically; Simultaneous estimation is the analysis of standards present in multiple combination dosage forms in the same time period. The advantages of simultaneous estimation lie in the fact that time-consuming extraction and separation can be avoided and the use of expensive reagents can be minimized. And the method is even more precise and accurate. A new high-performance liquid chromatographic HPLC method has been developed for the determination of paracetamol, phenylephrine hydrochloride, oxolamine citrate and chlorpheniramine maleate in combined pharmaceutical formulations and dosage forms. The separation was performed on an Agilent Zorbax SB. Several methods for the determination of chlorpheniramine maleate in pharmaceutical formulations have been reported in the literature. An aqueous titration method was proposed in which the excess HCl not absorbed by the free base of the drug is back-titrated. In addition, acid-base titrations were performed potentiometrically; In the presented work, a rapid and sensitive potentiometric determination of chlorpheniramine maleate CPM and pseudoephedrine hydrochloride PSE in pure form, in pharmaceutical preparation and in biological fluid was developed based on functionalized magnetic nanoparticles. An HPLC method has been described for simultaneous determination of chlorpheniramine maleate, phenylpropanolamine hydrochloride and paracetamol in formulation. This method is based on HPLC separation of the three drugs on the Thermo Hypersil Gold C 250 mm 4.6 mm, 5.0 under isocratic conditions and mobile. Simultaneous determination of paracetamol PAR, phenylephrine hydrochloride PHE and chlorpheniramine maleate CLP was performed by PLS1, PCR and HLA using data extracted from the UV-visible spectrum of above-mentioned compounds. This method was developed for the determination of PAR, PHE and CLP in artificial samples and a new, rapid and sensitive method was developed and validated for the simultaneous determination of phenylephrine hydrochloride, paracetamol, chlorpheniramine maleate and dextromethorphan hydrobromide in pharmaceutical preparations. The separation was achieved at a C using a mobile gradient. A micellar electrokinetic chromatography MEKC method was developed for the determination of paracetamol PARA and chlorpheniramine maleate CPM in cold tablets. A separation of both drugs and of the seven other cold ingredients was achieved. using a sodium dihydrogen phosphate-sodium tetraborate buffer 10,