The Spread of Hutchinson Gilford Progeria Syndrome Essay
Abstract. Hutchinson - Gilford progeria syndrome HGPS is a sporadic, autosomal dominant disorder characterized by premature and accelerated aging symptoms leading to death at average age. usually due to cardiovascular complications. HGPS is caused by a de novo point mutation in the LMNA gene encoding the, Background: Hutchinson-Gilford progeria syndrome is a rare, sporadic, autosomal dominant syndrome that involves premature aging and usually results in death by the age of 10 years as a result of a myocardial infarction or myocardial infarction. heart attack. The genetic basis of most cases of this syndrome is a change from glycine GGC to glycine GGT in codon, Hutchinson-Gilford Progeria syndrome. Hutchinson-Gilford Progeria Syndrome is an extremely rare condition of premature aging that usually involves a sporadic autosomal dominant mutation and occurs in one million live births worldwide, according to a study conducted in the Netherlands. The use of an ABE to directly correct the pathogenic HGPS mutation in cultured fibroblasts derived from children with progeria and in a mouse model of HGPS demonstrates the potential of in vivo base editing as a possible treatment for HGPS and other genetic diseases due to its cause to be corrected immediately. Hutchinson - Gilford, Clinical features: Hutchinson - Gilford progeria syndrome HGPS is characterized by clinical features that typically develop in childhood and resemble some features of accelerated aging. Children with HGPS usually appear normal at birth. During the first year, a profound failure occurs. Characteristic facial features include the head and Hutchinson-Gilford Progeria Syndrome. HGPS is an extremely rare human premature aging disorder that causes death due to heart disease. Nearly all cases of HGPS are caused by aberrant splicing of the LMNA gene that results in the production of a mutant Lamin A protein called progerin.;