Pregabalin in the Treatment of Fibromyalgia Pain Syndrome Essay
Several studies examined the effectiveness and safety of different doses of pregabalin in fibromyalgia. However, the optimal protocol remains controversial. A Bayesian network meta. Results: A total of IV clinical trials associated with fibromyalgia were identified. Of these, the studies met the inclusion criteria for the current study. The drugs used in phase IV trials are milnacipran, duloxetine, pregabalin, a combination of tramadol and paracetamol, and. Background. Chronic musculoskeletal pain is the leading reason for referrals to pediatric rheumatologists. It can be caused by a variety of inflammatory or non-inflammatory conditions, including arthritis, hypermobility, fibromyalgia FM, growing pains, and complex regional pain syndrome CRPS. Increased musculoskeletal pain. Pregabalin is used. for the treatment of various types of chronic pain, such as migraine, spinal cord injury or fibromyalgia. The effectiveness of pregabalin for the treatment of any type of chronic pain for each individual patient may be reflected by the modulation of the protein interactions of α2δ, such as with neurexins, thrombospondins and NMDA receptors. Background: There is evidence that the urogenital pain of chronic prostatitis in chronic pelvic inflammatory pain syndrome CP CPPS may be neuropathic. Methods: This randomized, double-blind, placebo-controlled trial was conducted at tertiary care centers in North America to determine whether pregabalin, which has been proven, discontinuation rates due to adverse events were similar between treatment groups. Conclusion. Pregabalin mg per day was effective for the treatment of FMS and reduced symptoms of pain, disturbed sleep and fatigue compared to placebo. Pregabalin was well tolerated and improved global measures and health-related quality. Doses are mg mg per day. Low doses are used at the start of treatment to minimize side effects, but the dose is usually increased after a few weeks. Features of the study. In we looked for clinical trials in which gabapentin was used to treat pain due to fibromyalgia in adults. Anti epileptics. Medications designed to treat epilepsy are often helpful in reducing certain types of pain. Gabapentin Neurontin is sometimes helpful in reducing fibromyalgia symptoms, while pregabalin, Lyrica, was the first drug approved by the Food and Drug Administration to treat fibromyalgia. The exact cause of fibromyalgia is unknown, but it is likely due to a problem with the way the brain processes pain. Research shows that people with fibromyalgia have a lower pain threshold and experience increased intensity of pain signals or how the brain interprets pain sensations. Pregabalin is used to treat pain caused by fibromyalgia, or nerve pain in people with diabetes, diabetic neuropathy, herpes zoster post-herpetic neuralgia, or spinal cord injury. Pregabalin is also used in combination with other medications to treat partial seizures in adults and one-month-old children. WarningsFibromyalgia Syndrome FMS is a complex, multifactorial, chronic rheumatic disorder characterized by widespread body pain, often accompanied by stiffness, fatigue, sleep disturbances, cognitive impairment and psychiatric symptoms. All these complex symptoms have a profound impact on daily activities and quality of life and cause;