Oral pulsatile drug delivery systems Biology essay
Oral pulsatile drug delivery systems Alessandra Maroni Istituto di Chimica Farmaceutica e Tossicologica, Universit di Milano, V. le, I - Italy. maria.sangalli unimi.it Lucia Zema Istituto di Chimica Farmaceutica e Tossicologica, Universit di Milano, V. le, I - Italy. maria.sangalli unimi.itThis system is designed for chronopharmacotherapy based on the circadian rhythm. The rational principle for using pulsatile release applies to drugs with a constant drug release profile. Pulsatile drug delivery systems PDDS are therefore designed to deliver the drug at the right place, at the right time and in the right amount, depending on the circadian rhythm of the human body. Indeed, humans exhibit a 24-hour circadian rhythm that occurs in several physiological processes and is regulated by the suprachiasmatic system. Various systems such as capsular systems, osmotic systems, single and multi-unit systems based on the use of soluble or erodible polymer coating and use of tearable membranes based on the use of soluble or erodible polymer coating have been discussed in the article. Pulsatile drug delivery systems are gaining much interest because: 2. Overview of the current status of chronopharmaceutical drug delivery. The chronopharmaceutical technologies based on physical and/or chemical activation for controlled drug release intended for different routes of administration have been described in detail elsewhere 7 9 10. Examples of technologies that can be used for: Hypertension HTN is a disorder of the CV system . characterized by increased arterial blood pressure. Pulsatile drug delivery systems are in the spotlight today. This is due to their different. Summary and figures. Pulsatile drug delivery systems have been developed to deliver drugs based on the circadian behavior of diseases. This means that these systems will deliver the drug at the right time. Circadian rhythms influence a range of biological processes in the body, with the central clock or suprachiasmatic nucleus SCN in the brain synchronizing peripheral clocks throughout the body. These clocks are controlled by external signals, the most influential of which is the light-dark cycle, to synchronize with the external day; Objective: The aim of the current study was to develop a floating pulsatile drug delivery system of Losartan potassium LP tablets to achieve no drug release during treatment. The pulsatile drug delivery system has gained much importance in drug delivery technology in the years when the aim of the present work was to formulate and evaluate an oral pulsatile agent. 1 Introduction. Controlled drug delivery systems aim to maintain the plasma concentration of drugs within the therapeutic window for an extended period of time, ensuring sustainable therapeutic action. Recent advances in chronotherapeutics have led to the development of pulsatile drug delivery systems. delivered the drug effectively at a specific time. Diseases such as asthma, arthritis. In this study, “solid lipid microparticle” SLMs were designed to obtain a free-flow oral pulsatile delivery system that allows MLT to be used to fill sachets. SLMs obtained by spray solidification were then characterized in terms of particle size, morphology, fluidity, drug content, and release behavior in both simulated gastric and intestinal fluids. Lately, the emphasis has been more on developing effective ones,