The Abuse Potential of Propofol and Benzodiazepines Biology Essay
Midazolam is an imidazobenzodiazepine with moderate sedative potential and hypnotic, anxiolytic, amnestic and anticonvulsant properties. has a longer duration of action compared to midazolam, yet all benzodiazepines can accumulate in the body after prolonged use. on the other hand, it is a powerful sedative and since s, with the development of chlordiazepoxide and soon after diazepam, benzodiazepines quickly became popular medications secondary to their vastly superior safety profiles compared to earlier sedative-hypnotics such as barbiturates and other non- barbiturates. used to treat anxiety and insomnia; Benzodiazepines are effective for sedation and anxiolysis, but can also cause harm. All healthcare professionals, including physicians who prescribe these drugs, should be fully aware of the drug's adverse effects, misuse, abuse, and potential to develop physical dependence. Benzodiazepines are DEA scheduled IV. In addition to medical uses, propofol is abused for recreational purposes, usually by medical professionals who are unaware of the risk of dependence on this substance. The purpose of this review was to provide an overview of molecular, animal and clinical pharmacology data from the literature demonstrating the potential for abuse. Fospropofol, an intravenous IV water-soluble prodrug of propofol, is approved by the Food and Drug Administration (FDA) for the short-term sedation of adults undergoing diagnostic or therapeutic procedures under controlled anesthesia care MAC. is classified by the FDA as a schedule four C-IV controlled substance. Propofol 2,6-diisopropylphenol is a commonly used short-acting intravenous anesthetic. However, due to the risk of drug abuse and deaths from propofol, propofol is a controlled drug in Korea. This overview uses the analytical methods using liquid chromatography LC, gas chromatography mass spectrometry or LC,