The possible role of vitamin D in diabetes biology essay
Diabetes mellitus T1DM is an autoimmune disease resulting from the destruction of beta cells in pancreatic islets. Although it can occur at any age, T1DM usually manifests in adolescence, peaking around puberty. The incidence of T1DM is similar in both sexes during childhood, but males are more likely to exhibit it. 1 Introduction. Vitamin D deficiency is considered a global public health problem, especially because in most countries large proportions of the general population do not meet dietary vitamin D requirements as recommended in the Vitamin D Dietary Guidelines 1,2, 3,4,5,6,7,8,9,10. Vitamin D is important for musculoskeletal health and the dosage and duration of vitamin D supplementation are other important contributors to glycemic control outcomes in patients with diabetes. High doses of vitamin D have been shown to improve glycemic control outcomes and have been shown to be more effective at correcting -hydroxyvitamin D levels in individuals with vitamin D. Vitamin D deficiency has been linked to the development of diabetes. This review summarizes the role of vitamin D in maintaining normal insulin release from the β cells of the pancreatic beta cells. Diabetes is initiated by the occurrence of insulin resistance. The β cells can overcome this resistance by releasing more insulin, which prevents vitamin D from occurring. Vitamin D is a fat-soluble prohormone that is essential for the... maintain bone and muscle health by promoting the. absorption and metabolism of calcium and phosphate. Besides food. According to several animal and human studies, vitamin D appears to play an important role in the development of diabetic nephropathy. However, the possible renal protective effect of vitamin D and its influence on reversing pre-existing kidney damage remains questionable. At present, there are some hypotheses about the: In addition, vitamin improves the protective effects of other cells that participate in the innate immune system as a first barrier defense, such as keratinocytes, epithelial, intestinal, lung and corneal cells and placental trophoblasts. . Recent studies have assessed the role of vitamin D in the biology of ILCs 46, 47. Historically, vitamin D has been recognized as an essential component for the maintenance of the musculoskeletal system. The immunomodulatory role of vitamin D in health and disease has received considerable interest in recent years due to the many pathologies that share underlying immunological features in which vitamin D plays a role. Based on findings related to the role of vitamin D in insulin production and glucose homeostasis, studies have demonstrated a causal relationship between vitamin D deficiency and diabetes mellitus. 1 Introduction. Vitamin D deficiency increases the risk of injury and disability and reduces quality of life in patients due to its association with sarcopenia, a condition that leads to loss of muscle mass and subsequent loss of muscle function and strength 1,2,3. Therefore, it is necessary to understand the role of vitamin D. The 25-dihydroxyvitamin D3 1,25 OH 2D3 induces cellular Ca signals that regulate insulin secretion, while low vitamin D status may be a risk factor for T2D diabetes. In pancreatic β-cells, 1,25 OH 2D, through multiple Ca signaling pathways, synchronous Ca 2 os, vitamin D and its metabolites also have an antiproliferative effect on tumor cells in vitro. By summarizing recent work on the role of vitamin D in menopausal women and in animal models of menopause, this,.