A new essay on the current formulation of Diclofenac Dihtylamine
The aim of the present study was to develop an effective topical formulation of diclofenac diethylamine DDA, for eventual use as a topically applied analgesic lotion. A series of lotions were prepared with variable DDA but variable concentration of oleic acid permeation enhancer-turpentine oil binary mixture 1. Transdermal route is an alternative choice of route of administration for such drugs. The drug, Diclofenac Diethylamine, also possesses ideal properties such as poor bioavailability, short biological half-life of 2 hours, smaller dose of 25 mg, etc., to be formulated into a transdermal patch. Topical diclofenac has been studied in the treatment of musculoskeletal disorders. other than osteoarthritis. Mueller et al. investigated the degree and time course of pain intensity with the treatment of a diclofenac patch compared to placebo in subjects with an acute traumatic sports injury over a period of one week. Objective: A simple, rapid, accurate and reproducible development and validation of an RP-HPLC method for estimating Diclofenac Diethylamine in topical solution. Experimental conditions: The method was developed using Kromasil C8, 4.5 m column. Composition of the mobile phase was Buffer: Methanol 25:75 VV, Buffer. The diclofenac diethylamine DDA was incorporated into the MEG and its in vitro release and permeation profiles were performed using Franz-type diffusion cells. The results showed that the. Diclofenac is a drug used in the treatment and treatment of inflammatory conditions and pain. It belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs). This activity outlines the indications, mechanism of action, administration, side effect profile, contraindications, and other key factors for diclofenac in the clinical setting. For example, the pharmacokinetic parameters of diclofenac in skeletal muscle were variable and indistinguishable following topical administration of diclofenac diethylamine. gel compared to that of. This wok aims to provide a comprehensive analysis of the anti-inflammatory activity of diclofenac sodium gel, focusing on its mechanism of action, efficacy, safety profile and clinical applications. Diclofenac sodium gel is a commonly used nonsteroidal anti-inflammatory drug NSAID formulation designed for topical application, mainly,